[THE INFLUENCE OF MEXIDOL AND 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE HEMISUCCINATE ON LIPOFUSCINE CONTENT IN RAT BRAIN UNDER LOCAL PERMANENT ISCHEMIA CONDITIONS].

Abstract

Experiments on rats showed that 6- and 12-day course treatment by mexidol or 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate (at doses 200 mg/kg, i.p.) prevented the lipofuscin level increase in rat brain tissue, caused by occlusion of the left middle cerebral artery, both in the damaged and intact (right) cerebral hemispheres. Mexidol significantly decreased the concentration of lipofuscine after 12-days treatment, whereas 2-ethyl-6-methyl-3-hydroxypiridine hemisuccinate markedly decreased lipofuscine levels already after 6-day treatment.

• Authors: N R Mirzoyan, N A Bagdasaryan, C B Alikhanyan, V S Meliksetyan, M G Bagdasaryan, A M Kukhtarova
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 78 Issue 8 Pg. 3-6 ( 2015) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 26591573 (Publication Type: Journal Article)

Chemical References

• 2-methyl-6-ethyl-3-hydroxypyridine hemisuccinate
• Antioxidants
• Lipofuscin
• Picolines
• Pyridines
• emoxypine succinate

Topics

• Animals
• Antioxidants (pharmacology)
• Brain (metabolism, pathology)
• Brain Chemistry (drug effects)
• Brain Ischemia (drug therapy, metabolism, pathology)
• Lipofuscin (metabolism)
• Male
• Picolines (pharmacology)
• Pyridines (pharmacology)
• Rats