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An efficient green synthesis of 2-arylbenzothiazole analogues as potent antibacterial and anticancer agents.

Abstract
We have demonstrated a novel and green approach for the synthesis of 2-substituted benzothiazole analogues. A number of 2-aryl and heteroaryl benzothiazole scaffolds were synthesized using Amberlite IR-120 resin under microwave irradiation. The catalytic role and reusability of the resin was well established here. 2-Substituted benzothiazole analogues (3a-l) were also tested against several bacterial strains (Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Salmonella) and cancer cell lines (MCF-7 and HeLa). The stability of compound 2-phenyl benzothiazole (3a) and 2-pyridin-2-yl-benzothiazole (3k) in GSH (0.01mM dissolved in DMSO) was measured by UV-Vis spectroscopy. Compound 3k also shows remarkable fluorescence in MeOH.
AuthorsMohit Chhabra, Sohini Sinha, Swagata Banerjee, Priyankar Paira
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 26 Issue 1 Pg. 213-7 (Jan 01 2016) ISSN: 1464-3405 [Electronic] England
PMID26590102 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier Ltd. All rights reserved.
Chemical References
  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Benzothiazoles
Topics
  • Anti-Bacterial Agents (chemical synthesis, chemistry, pharmacology)
  • Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
  • Bacillus subtilis (drug effects)
  • Benzothiazoles (chemical synthesis, chemistry, pharmacology)
  • Cell Proliferation (drug effects)
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Escherichia coli (drug effects)
  • Green Chemistry Technology
  • HeLa Cells
  • Humans
  • MCF-7 Cells
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Salmonella (drug effects)
  • Staphylococcus aureus (drug effects)
  • Structure-Activity Relationship

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