Abstract |
We have demonstrated a novel and green approach for the synthesis of 2-substituted benzothiazole analogues. A number of 2-aryl and heteroaryl benzothiazole scaffolds were synthesized using Amberlite IR-120 resin under microwave irradiation. The catalytic role and reusability of the resin was well established here. 2-Substituted benzothiazole analogues (3a-l) were also tested against several bacterial strains (Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Salmonella) and cancer cell lines (MCF-7 and HeLa). The stability of compound 2-phenyl benzothiazole (3a) and 2-pyridin-2-yl-benzothiazole (3k) in GSH (0.01mM dissolved in DMSO) was measured by UV-Vis spectroscopy. Compound 3k also shows remarkable fluorescence in MeOH.
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Authors | Mohit Chhabra, Sohini Sinha, Swagata Banerjee, Priyankar Paira |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 26
Issue 1
Pg. 213-7
(Jan 01 2016)
ISSN: 1464-3405 [Electronic] England |
PMID | 26590102
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Ltd. All rights reserved. |
Chemical References |
- Anti-Bacterial Agents
- Antineoplastic Agents
- Benzothiazoles
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Topics |
- Anti-Bacterial Agents
(chemical synthesis, chemistry, pharmacology)
- Antineoplastic Agents
(chemical synthesis, chemistry, pharmacology)
- Bacillus subtilis
(drug effects)
- Benzothiazoles
(chemical synthesis, chemistry, pharmacology)
- Cell Proliferation
(drug effects)
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Escherichia coli
(drug effects)
- Green Chemistry Technology
- HeLa Cells
- Humans
- MCF-7 Cells
- Microbial Sensitivity Tests
- Molecular Structure
- Salmonella
(drug effects)
- Staphylococcus aureus
(drug effects)
- Structure-Activity Relationship
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