The tumor-targeting core-shell structured DTX-loaded PLGA@Au nanoparticles for chemo-photothermal therapy and X-ray imaging.

Abstract

In this study, an organic-inorganic hybrid nanocomposite was synthesized by deposition of Au onto the surface of docetaxel (DTX)-loaded poly (lactide-co-glycolide) (PLGA) nanoparticle cores to form the core-shell structured DTX-loaded PLGA@Au nanoparticles. The tumor targeting peptide, angiopep-2, was then introduced onto the gold nanoshell through Au-S bond, achieving drug delivery with active targeting capability. This novel system allowed combined chemotherapy and thermal therapy for cancer, resulting from DTX and gold nanoshell. The formation of tumor-targeting gold nanoshell surrounding PLGA nanocore, designated as ANG/GS/PLGA/DTX NPs, was confirmed by its surface plasmon resonance (SPR) band in the UV-Vis spectrum and by a transmission electron microscope (TEM). The release profiles of DTX from this system showed strong dependence on near-infrared (NIR) laser. Compared with DTX alone, the ANG/GS/PLGA/DTX NPs afforded much higher anti-tumor efficiency without obvious toxic effects. Besides, it also showed potential X-ray imaging ability. These results demonstrated that the tumor-targeting core-shell structured DTX-loaded PLGA@Au nanoparticles could be used as a multifunctional nanomaterial system with NIR-triggered drug-releasing properties for tumor-targeted chemo-photothermal therapy and theranostics.

• Authors: Yongwei Hao, Bingxiang Zhang, Cuixia Zheng, Rui Ji, Xiangyi Ren, Fangfang Guo, Shili Sun, Jinjin Shi, Hongling Zhang, Zhenzhong Zhang, Lei Wang, Yun Zhang
• Journal: Journal of controlled release : official journal of the Controlled Release Society (J Control Release) Vol. 220 Issue Pt A Pg. 545-555 (Dec 28 2015) ISSN: 1873-4995 [Electronic] Netherlands
• PMID: 26590021 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier B.V. All rights reserved.

Chemical References

• Angiopep-2
• Antineoplastic Agents
• Chlorides
• Contrast Media
• Drug Carriers
• Gold Compounds
• Peptides
• Taxoids
• Docetaxel
• Polylactic Acid-Polyglycolic Acid Copolymer
• Polyglycolic Acid
• Lactic Acid
• gold tetrachloride, acid

Topics

• Animals
• Antineoplastic Agents (administration & dosage, chemistry, pharmacokinetics)
• Cell Line, Tumor
• Chlorides (chemistry)
• Contrast Media (administration & dosage, chemistry, pharmacokinetics)
• Docetaxel
• Drug Carriers
• Drug Compounding
• Glioblastoma (diagnostic imaging, drug therapy, metabolism, pathology)
• Gold Compounds (chemistry)
• Humans
• Injections, Intravenous
• Lactic Acid (chemistry)
• Lasers
• Metal Nanoparticles
• Mice, Inbred BALB C
• Mice, Nude
• Peptides (chemistry, metabolism)
• Photochemotherapy (instrumentation, methods)
• Polyglycolic Acid (chemistry)
• Polylactic Acid-Polyglycolic Acid Copolymer
• Solubility
• Taxoids (administration & dosage, chemistry, pharmacokinetics)
• Temperature
• Theranostic Nanomedicine (methods)
• Tumor Burden (drug effects)
• Xenograft Model Antitumor Assays