Prostacyclin as a cerebroprotective agent against brain hypoxia.

Abstract

The cerebroprotective effect of prostacyclin (PGI2) was studied using the following methods: hypobaric hypoxia in mice, anoxic hypoxia in mice, complete ischemia by decapitation in mice, hypoventilation hypoxia in cats, and hypovolemic hypoxia in cats. PGI2 induced a dose-dependent prolongation of the survival time of mice, when administered either I.C.V. (0.001-10/micrograms/mice), I.V. (0.5-500/micrograms/kg), or I.P. (50-500/micrograms/kg). In the experiments on cats PGI2 (250 ng/kg/min I.V.) led to a significant improvement of the hypoxic ECoG. In another series of experiments, an interaction of some cerebroprotective agents with the anti-hypoxic effect of PGI2 was investigated. Piracetam, meclofenoxate, nicergoline, naftidrofuryl, cinnarizine, and nifedipine shifted the anti-hypoxic dose-response curve of PGI2 to the left indicating synergistic interaction. The results obtained suggest the function of PGI2 as a cerebroprotective prostanoid in brain hypoxia.

• Authors: R Nikolov
• Journal: Biomedica biochimica acta (Biomed Biochim Acta) Vol. 48 Issue 2-3 Pg. S183-7 ( 1989) ISSN: 0232-766X [Print] Germany
• PMID: 2658983 (Publication Type: Journal Article)

Chemical References

• Epoprostenol

Topics

• Animals
• Brain Ischemia (physiopathology)
• Cats
• Cerebral Ventricles (drug effects, physiology, physiopathology)
• Epoprostenol (administration & dosage, therapeutic use)
• Female
• Hypoxia, Brain (physiopathology, prevention & control)
• Injections, Intraventricular
• Male
• Mice
• Mice, Inbred Strains
• Shock (physiopathology, prevention & control)