Abstract | BACKGROUND: FINDINGS: CONCLUSIONS: The production of ac-PGP in brain in ischemia/reperfusion injury and its propensity to induce apoptosis in neurons may link MMP-mediated destruction of the extracellular matrix and opening of the blood-brain barrier to progressive neurodegeneration associated with the initiation and propagation of inflammation. Ac-PGP may be a novel neurotoxic inflammatory mediator involved in sustained inflammation and neurodegeneration in stroke and other neurological disorders associated with activation of MMPs.
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Authors | Jeff W Hill, Edwin M Nemoto |
Journal | Journal of neuroinflammation
(J Neuroinflammation)
Vol. 12
Pg. 214
(Nov 21 2015)
ISSN: 1742-2094 [Electronic] England |
PMID | 26588897
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Inflammation Mediators
- N-acetyl-proline-glycine-proline
- Oligopeptides
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Topics |
- Animals
- Apoptosis
(drug effects, physiology)
- Blotting, Western
- Brain
(immunology, metabolism, pathology)
- Brain Ischemia
(immunology, metabolism, pathology)
- Cells, Cultured
- Chromatography, Liquid
- Disease Models, Animal
- Immunohistochemistry
- Inflammation Mediators
(metabolism)
- Mass Spectrometry
- Neurons
(drug effects, metabolism)
- Oligopeptides
(metabolism, toxicity)
- Rats
- Rats, Sprague-Dawley
- Reperfusion Injury
(immunology, metabolism, pathology)
- Stroke
(immunology, metabolism, pathology)
- Up-Regulation
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