Neurodevelopmental Implications of Neonatal Pain and Morphine Exposure.

Abstract

Neonatal pain management has evolved dramatically in the past few decades. Evidence is clear that neonates experience pain. Furthermore, we are increasingly aware of the detrimental effects of untreated neonatal pain during a critical period of neuronal maturation. Providing safe and effective pain relief is a primary goal of neonatal critical care specialists to ensure good outcomes. However, there are lingering concerns regarding the harmful effects of sedative-analgesics on the developing brain. Thus, striking a fine balance between effective analgesia and avoiding serious short- and long-term adverse effects from pain medications remains a major challenge for caregivers.

• Authors: Kalpashri Kesavan
• Journal: Pediatric annals (Pediatr Ann) Vol. 44 Issue 11 Pg. e260-4 (Nov 2015) ISSN: 1938-2359 [Electronic] United States
• PMID: 26587818 (Publication Type: Journal Article, Review)
• Copyright: Copyright 2015, SLACK Incorporated.

Chemical References

• Morphine

Topics

• Child Development (drug effects)
• Humans
• Infant, Newborn
• Infant, Premature
• Morphine (adverse effects, pharmacokinetics)
• Pain (drug therapy)