Abstract | BACKGROUND: METHODS: This review is based on publications up to and including January 2015 that were retrieved by a systematic search in PubMed, the Cochrane Library, and Scopus. Randomized controlled trials of the effect of MBM programs (versus standard treatment) on cardiac events, overall mortality, and/or cardiac mortality were analyzed. Atherosclerosis, blood pressure, LDL cholesterol, and the body mass index (BMI) were chosen as secondary outcomes. Random-effects meta-analyses were performed. The risk of bias was assessed with the Cochrane tool. RESULTS: Twelve trials, performed on a total of 1085 patients, were included in the analysis. Significant differences between groups were found with respect to cardiac events (odds ratio [OR]: 0.38; 95% confidence interval [CI]: 0.23-0.61; p<0.01; heterogeneity [I2]: 0%), but not overall mortality (OR: 0.82; 95% CI: 0.46-1.45; p = 0.49; I2: 0%) or cardiac mortality (OR: 0.98; 95% CI: 0.43-2.25; p = 0.97; I2: 0%). Significant differences between groups were also found with respect to atherosclerosis (mean difference [MD] = -7.86% diameter stenosis; 95% CI: -15.06-[-0.65]; p = 0.03; I2: 0%) and systolic blood pressure (MD = -3.33 mm Hg; 95% CI: -5.76-[-0.91]; p<0.01; I2: 0%), but not with respect to diastolic blood pressure, LDL cholesterol, or BMI. CONCLUSION: In patients with CHD, MBM programs can lessen the occurrence of cardiac events, reduce atherosclerosis, and lower systolic blood pressure, but they do not reduce mortality. They can be used as a complement to conventional rehabilitation programs.
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Authors | Holger Cramer, Romy Lauche, Anna Paul, Jost Langhorst, Andreas Michalsen, Gustav Dobos |
Journal | Deutsches Arzteblatt international
(Dtsch Arztebl Int)
Vol. 112
Issue 45
Pg. 759-67
(Nov 06 2015)
ISSN: 1866-0452 [Electronic] Germany |
PMID | 26585187
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review)
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Topics |
- Combined Modality Therapy
(methods)
- Coronary Artery Disease
(diagnosis, mortality, prevention & control)
- Diet Therapy
(mortality, statistics & numerical data)
- Evidence-Based Medicine
- Exercise Therapy
(mortality, statistics & numerical data)
- Humans
- Mind-Body Therapies
(methods, mortality, statistics & numerical data)
- Relaxation Therapy
(mortality, statistics & numerical data)
- Secondary Prevention
(methods, statistics & numerical data)
- Survival Rate
- Treatment Outcome
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