Febrile Ulceronecrotic Mucha-Habermann Disease: Two Cases with Excellent Response to Methotrexate.

Abstract

Febrile ulceronecrotic Mucha-Habermann disease (FUMHD), a severe form of pityriasis lichenoides et varioliformis acuta (PLEVA), featuring large, ulcerative, necrotic skin plaques, high fever, and other systemic symptoms, is a rare disorder of unknown etiology. No randomized controlled trials have established treatment guidelines and multiple modalities are often employed, making it difficult to assess the efficacy of any single agent. We report two cases of this condition in which treatment with methotrexate plus antibiotic treatment for superinfection led to rapid improvement.

• Authors: Kelly Griffith-Bauer, Sabra L Leitenberger, Alfons Krol
• Journal: Pediatric dermatology (Pediatr Dermatol) 2015 Nov-Dec Vol. 32 Issue 6 Pg. e307-8 ISSN: 1525-1470 [Electronic] United States
• PMID: 26584702 (Publication Type: Journal Article)
• Copyright: © 2015 Wiley Periodicals, Inc.

Chemical References

• Cephalexin
• Methotrexate

Topics

• Biopsy, Needle
• Cephalexin (administration & dosage)
• Child
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Drug Therapy, Combination
• Exanthema (diagnosis, etiology)
• Fever (diagnosis, etiology)
• Follow-Up Studies
• Herpes Simplex (diagnosis, drug therapy)
• Hospitalization
• Humans
• Immunohistochemistry
• Male
• Methotrexate (administration & dosage)
• Pityriasis Lichenoides (diagnosis, drug therapy)
• Rare Diseases
• Risk Assessment
• Sampling Studies
• Severity of Illness Index
• Superinfection (drug therapy, prevention & control)
• Treatment Outcome