Wilms Tumor in a Child With Bilateral Polycystic Kidneys and PHACE Syndrome: Successful Treatment Outcome Using Partial Nephrectomy and Chemotherapy.

Abstract

Congenital anomalies may be associated with Wilms tumor either as isolated anomalies or as part of a congenital malformation syndrome. Nephroblastoma occurring in association with polycystic kidneys is very rare. The optimal surgical management of nephroblastoma in the setting of polycystic kidneys is not defined because of the rarity of this presentation. PHACE syndrome includes posterior fossa anomalies, hemangioma, arterial lesions, cardiac abnormalities/coarctation of aorta, and eye abnormalities. We report a 17-month-old baby with bilateral polycystic kidneys and PHACE syndrome who developed nephroblastoma in the right polycystic kidney which was treated successfully with nephron-sparing partial nephrectomy and chemotherapy.

• Authors: Priyakumari Thankamony, Venugopal Sivarajan, Rari P Mony, Venugopal Muraleedharan
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 38 Issue 1 Pg. e6-9 (Jan 2016) ISSN: 1536-3678 [Electronic] United States
• PMID: 26583622 (Publication Type: Case Reports, Journal Article)

Topics

• Abnormalities, Multiple (pathology)
• Aortic Coarctation (complications)
• Eye Abnormalities (complications)
• Female
• Humans
• Infant
• Kidney Neoplasms (complications, pathology, surgery)
• Nephrectomy
• Neurocutaneous Syndromes (complications)
• Polycystic Kidney Diseases (complications)
• Syndrome
• Wilms Tumor (complications, pathology, surgery)