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Chemical Profiles and Protective Effect of Hedyotis diffusa Willd in Lipopolysaccharide-Induced Renal Inflammation Mice.

Abstract
Protective effect of Hedyotis diffusa (H. diffusa) Willd against lipopolysaccharide (LPS)-induced renal inflammation was evaluated by the productions of cytokines and chemokine, and the bioactive constituents of H. diffusa were detected by the ultra-fast liquid chromatography-diode array detector-quadrupole-time of flight mass spectrometry (UFLC-DAD-Q-TOF-MS/MS) method. As the results showed, water extract of H. diffusa (equal to 5.0 g/kg body weight) obviously protected renal tissues, significantly suppressed the productions of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, and monocyte chemoattractant protein (MCP)-1, as well as significantly promoted the production of IL-10 in serum and renal tissues. According the chemical profiles of H. diffusa, flavonoids, iridoid glycosides and anthraquinones were greatly detected in serum from H. diffusa extract treatment mice. Two main chemotypes, including eight flavonoids and four iridoid glycosides were found in renal tissues from H. diffusa extract treatment mice. The results demonstrated that water extract of H. diffusa had protective effect on renal inflammation, which possibly resulted from the bioactive constituents consisting of flavonoids, iridoids and anthraquinones.
AuthorsJian-Hong Ye, Meng-Hua Liu, Xu-Lin Zhang, Jing-Yu He
JournalInternational journal of molecular sciences (Int J Mol Sci) Vol. 16 Issue 11 Pg. 27252-69 (Nov 13 2015) ISSN: 1422-0067 [Electronic] Switzerland
PMID26580602 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Chemokines
  • Cytokines
  • Lipopolysaccharides
  • Plant Extracts
  • Protective Agents
Topics
  • Animals
  • Chemokines (biosynthesis)
  • Chromatography, High Pressure Liquid
  • Cytokines (biosynthesis)
  • Hedyotis (chemistry)
  • Lipopolysaccharides (adverse effects)
  • Macrophages (metabolism, pathology)
  • Mice
  • Nephritis (chemically induced, drug therapy, metabolism, pathology)
  • Plant Extracts (chemistry, pharmacology)
  • Protective Agents (chemistry, pharmacology)
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Tandem Mass Spectrometry

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