Uromodulin, kidney function, cardiovascular disease, and mortality.

Abstract

Uromodulin (Tamm-Horsfall protein) is exclusively produced by the kidney and is the most abundant protein excreted in normal urine. The level of uromodulin in urine could represent a useful biomarker for renal tubular function. The study of Garimella et al. adds elements into the debate, by suggesting that, in elderly adults, low urinary uromodulin concentrations in spot urine identify people at risk of progressive kidney disease and mortality above and beyond established markers of kidney disease.

• Authors: Olivier Devuyst, Murielle Bochud
• Journal: Kidney international (Kidney Int) Vol. 88 Issue 5 Pg. 944-6 (Nov 2015) ISSN: 1523-1755 [Electronic] United States
• PMID: 26579681 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Comment)

Chemical References

• Biomarkers
• Uromodulin

Topics

• Biomarkers (urine)
• Cardiovascular Diseases (metabolism)
• Humans
• Kidney (metabolism)
• Kidney Diseases (metabolism)
• Uromodulin (urine)