Abstract | OBJECTIVE: To determine the most adequate strategies for the prevention and treatment of the acute adverse effects of the use of antipsychotics. METHODS: A clinical practice guideline was elaborated under the parameters of the Methodological Guide of the Ministerio de Salud y Protección Social to identify, synthesize and evaluate the evidence and make recommendations about the treatment and follow-up of adult patients with schizophrenia. A systematic literature search was carried out. The evidence was presented to the Guideline Developing Group and recommendations, employing the GRADE system, were produced. RESULTS: The non-pharmacological interventions such as nutritional counseling by a nutritionist, exercise and psychotherapy are effective in preventing weight gain with the use of antipsychotics. (Kg Weight reduction in DM of -3.05 (-4.16, -1.94)). The antipsychotic change from olanzapine to aripiprazole showed weight loss and decreased BMI (decreased weight in KG DM -3.21 (-9.03, -2.61). The use of beta blockers was ineffective in reducing akathisia induced by antipsychotic; using as outcome the 50% reduction of symptoms of akathisia comparing beta-blockers with placebo RR was 1.4 (0.59, 1.83). CONCLUSION:
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Authors | Álvaro Enrique Arenas Borrero, Carlos Gómez Restrepo, Adriana Patricia Bohórquez Peñaranda, Ángela Vélez Traslaviña, Sergio Mario Castro Díaz, Luis Eduardo Jaramillo González, Jenny García Valencia |
Journal | Revista colombiana de psiquiatria
(Rev Colomb Psiquiatr)
Vol. 44 Suppl 1
Pg. 66-74
( 2014)
ISSN: 0034-7450 [Print] Colombia |
Vernacular Title | Prevención y tratamiento de los efectos adversos agudos más frecuentes por el uso de antipsicóticos en pacientes adultos con diagnóstico de esquizofrenia. |
PMID | 26576463
(Publication Type: English Abstract, Journal Article)
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Copyright | Copyright © 2014 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved. |