Rosacea is a chronic cutaneous condition with a prevalence rate ranging from 9.6% to 22% in recent studies. Facial
erythema (transient and permanent) is considered a common denominator that is frequently observed in all subtypes of
rosacea and is estimated to affect more than 40 million people worldwide.
Brimonidine tartrate is a selective α2-adrenergic receptor agonist and is the first topical treatment approved for facial
erythema of
rosacea. Clinical trials have demonstrated that
brimonidine tartrate provided significantly greater efficacy, compared to vehicle, for the treatment of moderate to severe
erythema of
rosacea. In addition,
brimonidine tartrate has demonstrated a rapid onset of effect, duration of action throughout the day, and good safety profile in studies of up to 1 year. This review critically discusses the role of
brimonidine tartrate for the treatment of facial
erythema of
rosacea by examining both clinical study data and real-world dermatologist experiences across a wide spectrum of treated patients, and concludes that it is a significant therapeutic option in the management of an unmet need of this
chronic condition.