HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Cerebrospinal Fluid Biomarkers in Dementia Patients with Cerebral Amyloid Angiopathy.

AbstractOBJECTIVE:
To study the changes of biomarkers in cerebrospinal fluid (CSF) in cerebral amyloid angiopathy (CAA) dementia and Alzheimer(')s disease.
METHODS:
Levels of amyloid protein β (Aβ42, Aβ40) and phosphorylated Tau-protein (P-tau) in CSF and ratio of Aβ42/Aβ40 were tested in 5 cases with CAA dementia and 20 cases with Alzheimer's disease collected at Peking Union Medical College Hospital from December 2001 to March 2011.
RESULTS:
The levels of Aβ42, Aβ40, and P-tau in CSF and ratio of Aβ42/Aβ40 were (660.4 ± 265.2) ng/L, (7111.0 ± 1033.4) ng/L, (71.8 ± 51.5) ng/L, and 0.077 ± 0.033, respectively in CAA dementia and (663.6 ± 365.6) ng/L, (5115.0 ± 2931.1) ng/L, (47.7 ± 38.8) ng/L, and 0.192 ± 0.140, respectively in Alzheimer's disease patients. There were no statistically significant differences between CAA dementia and Alzheimer's disease in terms of these CSF biomarkers (all P>0.05).
CONCLUSION:
Measurements of CSF biomarkers may not be helpful in differential diagnosis of CAA and Alzheimer's disease.
AuthorsYan-feng Li, Fang-fang Ge, Yong Zhang, Hui You, Zhen-xin Zhang
JournalChinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih (Chin Med Sci J) Vol. 30 Issue 3 Pg. 170-3 (Sep 2015) ISSN: 1001-9294 [Print] China
PMID26564416 (Publication Type: Journal Article)
Chemical References
  • Amyloid beta-Peptides
  • Apolipoproteins E
  • Biomarkers
  • tau Proteins
Topics
  • Aged
  • Aged, 80 and over
  • Amyloid beta-Peptides (cerebrospinal fluid)
  • Apolipoproteins E (genetics)
  • Biomarkers (cerebrospinal fluid)
  • Cerebral Amyloid Angiopathy (cerebrospinal fluid)
  • Dementia (cerebrospinal fluid)
  • Humans
  • Male
  • tau Proteins (cerebrospinal fluid)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: