Acute dystonic reaction due to dexketoprofen trometamol.

Abstract

Dexketoprofentrometamol (DKP), is a tromethamine salt of the water-soluble S-enantiomer of ketoprofen. As with all other non-steroidal anti-inflammatory agents, the most common side effect of DKP is gastric complications. In this paper, we report a case of dystonic reaction after intravenous DKP use. A 24-year-old man was admitted to our hospital after suffering a leg burn from boiling oil. He had no drug hypersensitivity. An intravenous preparation containing the active ingredient DKP was injected for analgesia, after which the patient experienced an involuntary flexion response in both upper extremities. With a suspected diagnosis of dystonia, biperiden lactate 5 mg/ml was administered via the intramuscular route and the contractions abated within 30 seconds of the injection.As non-steroidal anti-inflammatory agents are commonly used and prescribed in emergency departments, it should be kept in mind that an acute dystonic reaction can develop against one of these agents, DKP.

• Authors: Afsin Emre Kayipmaz, Tufan Akin Giray, Suleyman Serdar Tasci, Suleyman Serdar Tasci, Cemil Kavalci, Ummu Gulsum Kocalar
• Journal: JPMA. The Journal of the Pakistan Medical Association (J Pak Med Assoc) Vol. 65 Issue 11 Pg. 1231-2 (Nov 2015) ISSN: 0030-9982 [Print] Pakistan
• PMID: 26564300 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Tromethamine
• Ketoprofen
• dexketoprofen trometamol

Topics

• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Dystonia (chemically induced)
• Humans
• Ketoprofen (adverse effects, analogs & derivatives)
• Male
• Pain (drug therapy)
• Tromethamine (adverse effects)
• Young Adult