Abstract |
A 70-year-old woman presented with frequent episodes of hypoglycemia. Imaging revealed a 6-cm pancreatic mass with several liver lesions. The pancreatic mass was resected and confirmed to be a well-differentiated insulinoma. Surgery improved but did not resolve her hypoglycemic episodes, and she was referred for peptide receptor radionuclide therapy with 177Lu-DOTATATE to treat her residual disease. A modified protocol with a continuous IV dextrose infusion was used, and the treatments were well tolerated. After 4 induction and 2 maintenance treatments, her hypoglycemic symptoms resolved completely and her disease stabilized. She has been progression free for 24 months.
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Authors | William Makis, Karey McCann, Alexander J B McEwan |
Journal | Clinical nuclear medicine
(Clin Nucl Med)
Vol. 41
Issue 1
Pg. 53-4
(Jan 2016)
ISSN: 1536-0229 [Electronic] United States |
PMID | 26562579
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Organometallic Compounds
- Receptors, Peptide
- lutetium Lu 177 dotatate
- Octreotide
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Topics |
- Aged
- Female
- Humans
- Insulinoma
(pathology, radiotherapy)
- Neoplasm Metastasis
- Neuroendocrine Tumors
(pathology, radiotherapy)
- Octreotide
(analogs & derivatives, therapeutic use)
- Organometallic Compounds
(therapeutic use)
- Pancreatic Neoplasms
(pathology, radiotherapy)
- Receptors, Peptide
(metabolism)
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