HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Fisher Syndrome and Bickerstaff Brainstem Encephalitis].

Abstract
Fisher syndrome has been regarded as a peculiar inflammatory neuropathy with ophthalmoplegia, ataxia, and areflexia, whereas Bickerstaff brainstem encephalitis has been considered a pure central nervous system disease characterized by ophthalmoplegia, ataxia, and consciousness disturbance. Both disorders share common features including preceding infection, albumin-cytological dissociation, and association with Guillain-Barré syndrome. The discovery of anti-GQ1b IgG antibodies further supports the view that the two disorders represent a single disease spectrum. The lesions in Fisher syndrome and Bickerstaff brainstem encephalitis are presumably determined by the expression of ganglioside GQ1b in the human peripheral and central nervous systems. Bickerstaff brainstem encephalitis is likely to represent a variant of Fisher syndrome with central nervous system involvement.
AuthorsSatoshi Kuwabara
JournalBrain and nerve = Shinkei kenkyu no shinpo (Brain Nerve) Vol. 67 Issue 11 Pg. 1371-6 (Nov 2015) ISSN: 1881-6096 [Print] Japan
PMID26560952 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Autoantibodies
  • Gangliosides
  • GQ1b ganglioside
Topics
  • Animals
  • Autoantibodies (blood)
  • Brain Stem (immunology)
  • Encephalitis (diagnosis, epidemiology, immunology)
  • Gangliosides (immunology)
  • Guillain-Barre Syndrome (diagnosis, epidemiology, therapy)
  • Humans
  • Miller Fisher Syndrome (diagnosis, epidemiology, therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: