Protective Effect of Eburicoic Acid of the Chicken of the Woods Mushroom, Laetiporus sulphureus (Higher Basidiomycetes), Against Gastric Ulcers in Mice.

Abstract

In this study, we investigated the anti-inflammatory and tumor-inhibiting effects of eburicoic acid, the main bioactive component in the Laetiporus sulphureus, on gastric ulcers. A total of 48 Kunming mice were randomly divided into six groups: control, model, OL (omeprazole, 20 mg/kg/day, orally), EA-L (eburicoic acid, 10 mg/kg/day, orally), EA-M (eburicoic acid, 20 mg/kg/day, orally), and EA-H (eburicoic acid, 40 mg/kg/day, orally). Gastric ulcers were induced in mice by administering 80% ethanol containing 15 mg/mL aspirin (10.0 mL/kg, i.g.) 4 hours after drug administration on day 5. The ulcer index and H+/K+-ATPase activity were evaluated in vivo. Computer-aided molecular docking simulated the interaction between eburicoic acid and H+/K+-ATPase. The results showed that the oral administration of eburicoic acid protected the gastric mucosa from gastric lesions morphologically and especially attenuated H+/K+-ATPase activity. The results of this study indicate that the gastric protective effect of eburicoic acid might inhibit gastric acid.

• Authors: Junzhi Wang, Wenjun Sun, Huajun Luo, Haibo He, Weiqiao Deng, Kun Zou, Can Liu, Jing Song, Wenfeng Huang
• Journal: International journal of medicinal mushrooms (Int J Med Mushrooms) Vol. 17 Issue 7 Pg. 619-26 ( 2015) ISSN: 1940-4344 [Electronic] United States
• PMID: 26559696 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Ulcer Agents
• Protective Agents
• Lanosterol
• eburicoic acid
• H(+)-K(+)-Exchanging ATPase

Topics

• Animals
• Anti-Ulcer Agents (therapeutic use)
• Coriolaceae (chemistry)
• H(+)-K(+)-Exchanging ATPase (metabolism)
• Lanosterol (analogs & derivatives, chemistry, therapeutic use)
• Male
• Mice
• Molecular Structure
• Protective Agents (therapeutic use)
• Stomach Ulcer (pathology, prevention & control)