Synthesis and alpha-glucosidase-inhibiting activity of a new alpha-glucosidase inhibitor, 4-O-alpha-D-glucopyranosylmoranoline and its N-substituted derivatives.

Abstract	Various N-substituted derivatives of 4-O-alpha-D-glucopyranosylmoranoline have been synthesized, and their inhibitory activities against rabbit sucrase and maltase have been measured, as well as their effects on postprandial hyperglycemia in the sucrose-loaded rat, 4-O-alpha-D-Glucopyranosylmoranoline was also shown to have potent hypoglycemic activity in starch-loaded dogs.
Authors	Y Yoshikuni, Y Ezure, T Seto, K Mori, M Watanabe, H Enomoto
Journal	Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 37 Issue 1 Pg. 106-9 (Jan 1989) ISSN: 0009-2363 [Print] Japan
PMID	2655949 (Publication Type: Journal Article)
Chemical References	Blood Glucose Disaccharides Glycoside Hydrolase Inhibitors 1-Deoxynojirimycin 4-O-glucopyranosylmoranoline
Topics	1-Deoxynojirimycin (analogs & derivatives) Animals Blood Glucose (metabolism) Chemical Phenomena Chemistry Disaccharides (chemical synthesis, pharmacology) Dogs Glycoside Hydrolase Inhibitors Male Rabbits Rats

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