Abstract | INTRODUCTION: METHODS: We compared the effects of long-term statin therapy (average follow-up time 5.79 years) in terms of major adverse cardiovascular events ( MACE), all-cause death, and cardiac death among 570 CAD patients with or without CKD and 147 CKD only patients. RESULTS: The all-cause death and cardiac death of the patients with CAD and CKD (24.4% and 20.4%) doubled those of CAD only patients (10.7% and 9.1%) (P < 0.001). Long-term statin therapy dramatically reduced the rates of both MACE and all-cause death/cardiac death (by 20.5% and 28.6%/27.7%, resp.) in CAD and CKD patients. CKD only patients had no significant adverse clinical outcomes and were not responsive to long-term statin therapy. CONCLUSION: Chinese CAD patients with CKD had dramatically high rates of adverse clinical outcomes; for them, long-term statin therapies were exceptionally effective in improving morbidity and mortality. CKD patients who had no cardiovascular disease initially can prognose good clinical outcomes and do not require statin treatment.
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Authors | Huiling Huang, Chunmei Zeng, Yuedong Ma, Yili Chen, Cong Chen, Chen Liu, Yugang Dong |
Journal | Disease markers
(Dis Markers)
Vol. 2015
Pg. 252564
( 2015)
ISSN: 1875-8630 [Electronic] United States |
PMID | 26557729
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Topics |
- Aged
- Case-Control Studies
- Coronary Artery Disease
(complications, drug therapy)
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(administration & dosage, adverse effects, therapeutic use)
- Male
- Middle Aged
- Renal Insufficiency, Chronic
(complications)
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