HTLV-1 ORF-I Encoded Proteins and the Regulation of Host Immune Response: Viral Induced Dysregulation of Intracellular Signaling.

Abstract

The human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus associated with both proliferative and inflammatory disorders. This virus causes a persistent infection, mainly in CD4+ T lymphocyte. The ability to persist in the host is associated with the virus capacity to evade the immune response and to induce infected T-cell proliferation, once the HTLV-1 maintains the infection mainly by clonal expansion of infected cells. There are several evidences that ORF-I encoded proteins, such as p12 and p8, play an important role in this context. The present study will review the molecular mechanisms that HTLV-1 ORF-I encoded proteins have to induce dysregulation of intracellular signaling, in order to escape from immune response and to increase the infected T-cell proliferation rate. The work will also address the impact of ORF-I mutations on the human host and perspectives in this study field.

• Authors: Carolina Rosadas, Marzia Puccioni-Sohler
• Journal: Journal of immunology research (J Immunol Res) Vol. 2015 Pg. 498054 ( 2015) ISSN: 2314-7156 [Electronic] Egypt
• PMID: 26557721 (Publication Type: Journal Article, Review)

Chemical References

• Intracellular Signaling Peptides and Proteins
• Viral Regulatory and Accessory Proteins
• p12I protein, Human T-lymphotropic virus 1

Topics

• Animals
• CD4-Positive T-Lymphocytes (immunology)
• Cell Proliferation
• Host-Pathogen Interactions
• Human T-lymphotropic virus 1 (genetics, physiology)
• Humans
• Immune Evasion
• Intracellular Signaling Peptides and Proteins (genetics, metabolism)
• Killer Cells, Natural (immunology)
• Lymphocyte Activation
• Mutation
• Signal Transduction
• T-Lymphocytes (immunology, virology)
• T-Lymphocytes, Cytotoxic (immunology)
• Viral Regulatory and Accessory Proteins (genetics, physiology)