Comparison of Ocular Pulse Amplitude Lowering Effects of Preservative-Free Tafluprost and Preservative-Free Dorzolamide-Timolol Fixed Combination Eyedrops.

Abstract

PURPOSE:

To compare the ocular pulse amplitude (OPA) lowering effects of preservative-free tafluprost and dorzolamide-timolol fixed combination (DTFC) using dynamic contour tonometry.

METHODS:

In total, 66 eyes of 66 patients with normal tension glaucoma (NTG) (n = 34) or primary open angle glaucoma (POAG) (n = 32) were included. Patients were divided into two groups: the preservative-free tafluprost-treated group (n = 33) and the preservative-free DTFC-treated group (n = 33). Intraocular pressure (IOP) was measured using Goldmann applanation tonometry (GAT). OPA was measured using dynamic contour tonometry; corrected OPA (cOPA) was calculated at baseline and at 1 week and 1, 3, and 6 months after treatment.

RESULTS:

After 6 months of treatment, tafluprost significantly reduced IOP (P < 0.001). The OPA lowering effects differed significantly between the two treatment groups (P = 0.003). The cOPA-lowering effect of tafluprost (1.09 mmHg) was significantly greater than that of DTFC (0.36 mmHg) after 6 months of treatment (P = 0.01).

CONCLUSIONS:

Tafluprost and DTFC glaucoma treatments provided marked OPA and IOP lowering effects. Tafluprost had a greater effect than DTFC; thus, this drug is recommended for patients at risk of glaucoma progression, due to the high OPA caused by large fluctuations in IOP.

• Authors: Du Ri Seo, Seung Joo Ha
• Journal: BioMed research international (Biomed Res Int) Vol. 2015 Pg. 435874 ( 2015) ISSN: 2314-6141 [Electronic] United States
• PMID: 26557671 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Combinations
• Ophthalmic Solutions
• Preservatives, Pharmaceutical
• Prostaglandins F
• Sulfonamides
• Thiophenes
• dorzolamide-timolol combination
• tafluprost
• Timolol
• dorzolamide

Topics

• Drug Combinations
• Eye (drug effects)
• Female
• Glaucoma, Open-Angle (drug therapy)
• Humans
• Intraocular Pressure (drug effects)
• Low Tension Glaucoma (drug therapy)
• Male
• Middle Aged
• Ocular Hypertension (drug therapy)
• Ophthalmic Solutions (administration & dosage)
• Preservatives, Pharmaceutical (administration & dosage)
• Prostaglandins F (administration & dosage)
• Retrospective Studies
• Sulfonamides (administration & dosage)
• Thiophenes (administration & dosage)
• Timolol (administration & dosage)
• Tonometry, Ocular (methods)