Anti-α-enolase is a prognostic marker in postoperative lung cancer patients.

Abstract	Our previous studies suggest that antibodies against ENO1 (anti-ENO1 Ab) have a protective role in patients with non-small cell lung carcinoma. In this study, we evaluated the prognostic value of anti-ENO1 Ab levels in non-small cell lung carcinoma patients undergoing surgery. Circulating levels of anti-ENO1 Ab were assessed in 85 non-small cell lung carcinoma patients before and after surgery, and were correlated with clinical outcome. After surgery, patients with a higher increase of anti-ENO1 Ab had a lower hazard ratio and a better progression-free survival. Using animal models, we demonstrated that tumor cells reduce the circulating levels of anti-ENO1 Ab through physical absorption and neutralization of anti-ENO1 Ab with surface-expressed and secreted ENO1, respectively. Mice transplanted with ENO1-overexpressing tumors generated ENO1-specific regulatory T cells to suppress the production of anti-ENO1 Ab. Our results suggest that the increase of anti-ENO1 Ab may reflect anti-tumor immune responses and serve as a prognostic marker in postoperative lung cancer patients.
Authors	Kuan-Chung Hsiao, Neng-Yao Shih, Pei-Yi Chu, Yi-Mei Hung, Jia-Yi Liao, Shao-Wen Chou, Yi-Yuan Yang, Gee-Chen Chang, Ko-Jiunn Liu
Journal	Oncotarget (Oncotarget) Vol. 6 Issue 33 Pg. 35073-86 (Oct 27 2015) ISSN: 1949-2553 [Electronic] United States
PMID	26551021 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antibodies, Neoplasm Biomarkers, Tumor DNA-Binding Proteins Tumor Suppressor Proteins ENO1 protein, human Phosphopyruvate Hydratase
Topics	Aged Animals Antibodies, Neoplasm (blood) Biomarkers, Tumor (analysis, blood, immunology) Carcinoma, Non-Small-Cell Lung (blood, immunology, mortality) DNA-Binding Proteins (immunology) Disease-Free Survival Enzyme-Linked Immunosorbent Assay Female Humans Kaplan-Meier Estimate Lung Neoplasms (blood, immunology, mortality) Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Middle Aged Phosphopyruvate Hydratase (immunology) Prognosis Tumor Suppressor Proteins (immunology)

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