Protective effects of 5,7,4'-trihydroxy-6,3'dimethoxy-flavone 5-O-α-l-rhamnopyranoside, isolated from Annona squamosa leaves in thyrotoxicosis and in hepatic lipid peroxidation in rats.

Abstract

Hitherto unknown protective effects of 5,7,4'-trihydroxy-6,3'dimethoxy-flavone 5-O-α-l-rhamnopyranoside (THDMF-Rha); isolated from Annona squamosa leaves were evaluated in l-thyroxine (l-T4)-induced thyrotoxicosis in rats. Administration of l-T4 at 500μg/kg body weight for 12days increased the levels of serum thyroid hormones, the activity of 5'-monodeiodinase-I (5'DI) and hepatic glucose-6-phosphatase (G-6Pase) as well as lipid peroxidation (LPO); with a parallel decrease in the levels of cellular antioxidants and serum lipids. However, administration of the isolated THDMF-Rha at a pre-standardized dose for 15days ameliorated the l-T4-induced alterations in the levels of thyroid hormones, hepatic LPO, G-6-Pase, 5'DI activity, and cellular levels of antioxidants and improved the status of different serum lipids, suggesting its antithyroidal and antioxidative potential. As compared to standard antithyroid drug, propylthiouracil, THDMF-Rha appeared to be more promising.

• Authors: Sunanda Panda, Anand Kar
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 25 Issue 24 Pg. 5726-8 (Dec 15 2015) ISSN: 1464-3405 [Electronic] England
• PMID: 26547692 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• 5,7,4'-trihydroxy-6,3'-dimethoxy-flavone-5-O-rhamnopyranoside
• Antioxidants
• Flavones
• Flavonoids
• Monosaccharides
• Protective Agents
• Thyroid Hormones
• Triglycerides
• Cholesterol
• Glucose-6-Phosphatase
• Rhamnose

Topics

• Animals
• Annona (chemistry, metabolism)
• Antioxidants (metabolism)
• Cholesterol (blood)
• Flavones (chemistry, isolation & purification, pharmacology)
• Flavonoids
• Glucose-6-Phosphatase (metabolism)
• Lipid Peroxidation (drug effects)
• Liver (enzymology)
• Monosaccharides
• Plant Leaves (chemistry, metabolism)
• Protective Agents (isolation & purification, pharmacology, therapeutic use)
• Rats
• Rhamnose (analogs & derivatives, chemistry, isolation & purification, pharmacology)
• Thyroid Hormones (blood)
• Thyrotoxicosis (drug therapy, metabolism, pathology)
• Triglycerides (blood)