Association between Peptidylarginine Deiminase Type 4 rs1748033 Polymorphism and Susceptibility to Rheumatoid Arthritis in Zahedan, Southeast Iran.

Abstract

There are controversial reports regarding the role of peptidylarginine deiminase type 4 (PADI4) gene polymorphisms and risk of Rheumatoid arthritis (RA). The aim of the present study was to investigate the impact of PADI4 rs1748033 polymorphism and susceptibility to RA in a sample of the Iranian population. This case-control study was done on 150 patients with RA and 150 healthy subjects.PADI4 rs1748033 genotyping was done using amplification refractory mutation system- polymerase chain reaction (ARMS-PCR) assay. The PADI4 rs1748033 variant increased the risk of RA in codominant (OR=1.67, 95%CI=1.03-2.71, p=0.048, CT vs CC; OR=2.73, 95%CI=1.25-5.97, p=0.013, TT vs CC) and dominant (OR=1.84, 95%CI=1.15-2.92, p=0.014, CT+TT vs CC) tested inheritance models. In addition, the PADI4 rs1748033 T allele increased the risk of RA (OR=1.63, 95%CI=1.16-2.29, p=0.006) in comparison with C allele. In conclusion, our finding indicated that PADI4 rs1748033 gene polymorphism increased the risk of RA in a sample of the Iranian population.

• Authors: Mohammad Hashemi, Zahra Zakeri, Hamed Taheri, Gholamreza Bahari, Mohsen Taheri
• Journal: Iranian journal of allergy, asthma, and immunology (Iran J Allergy Asthma Immunol) Vol. 14 Issue 3 Pg. 255-60 (Jun 2015) ISSN: 1735-1502 [Print] Iran
• PMID: 26546893 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hydrolases
• PADI4 protein, human
• Protein-Arginine Deiminase Type 4
• Protein-Arginine Deiminases

Topics

• Adult
• Arthritis, Rheumatoid (genetics)
• Case-Control Studies
• Female
• Genetic Predisposition to Disease
• Humans
• Hydrolases (genetics)
• Male
• Middle Aged
• Polymorphism, Genetic
• Protein-Arginine Deiminase Type 4
• Protein-Arginine Deiminases