Abstract | RATIONALE: OBJECTIVES: We aimed to investigate the effect of hippocampal CysLT1R downregulation on depressive behaviors and neuroinflammatory responses in mice exposed to chronic mild stress (CMS). RESULTS: We firstly found that expression of hippocampal CysLT1R was gradually increased over CMS exposure, while 3 weeks treatment with fluoxetine reversed the increment of hippocampal CysLT1R expression. Hippocampal CysLT1R knockdown suppressed CMS-induced depressive-like behaviors as evidenced by decreases in immobility time in tail suspension test (TST), decreased latency to feed in novelty-suppressed feeding (NSF) test, and by increase in the number of entries and decrease in time spent in the open arm in elevated plus maze (EPM) test. Increments of hippocampal NF-κB p65, IL-1β, and TNF-α induced by CMS were also prevented by hippocampal CysLT1R knockdown beforehand. CONCLUSIONS: Hippocampal CysLT1R participates in depression, and knockdown of hippocampal CysLT1R prevents CMS-induced depressive-like behaviors and neuroinflammation, suggesting that suppression of CysLT1R could prevent the development of depression.
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Authors | Xu-Ben Yu, Rong-Rong Dong, Hui Wang, Jing-Ran Lin, Yun-Qi An, Yong Du, Su-Su Tang, Mei Hu, Yan Long, Hong-Bin Sun, Ling-Yi Kong, Hao Hong |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 233
Issue 9
Pg. 1739-49
(May 2016)
ISSN: 1432-2072 [Electronic] Germany |
PMID | 26546369
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antidepressive Agents, Second-Generation
- Cytokines
- Receptors, Leukotriene
- Fluoxetine
- leukotriene D4 receptor
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Topics |
- Animals
- Antidepressive Agents, Second-Generation
(pharmacology)
- Anxiety
(psychology)
- Cytokines
(metabolism)
- Depression
(etiology, genetics)
- Eating
(drug effects)
- Fluoxetine
(pharmacology)
- Gene Knockdown Techniques
- Hindlimb Suspension
(psychology)
- Hippocampus
(drug effects, metabolism)
- Inflammation
(complications, genetics)
- Male
- Mice
- Mice, Inbred ICR
- Receptors, Leukotriene
(genetics)
- Stress, Psychological
(metabolism, psychology)
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