Management of Meningitis Caused by Multi Drug-Resistant Acinetobacter Baumannii: Clinical, Microbiological and Pharmacokinetic Results in a Patient Treated with Colistin Methanesulfonate.

Abstract

This paper reports on a 71- year-old Caucasian male who underwent neurosurgery for an oligodendroglioma, followed by a cranial-sinus fistula and cerebrospinal fluid rhinorrhea. The clinical course was complicated due to an extensively drug-resistant Acinetobacter baumannii meningitis. The patient was treated with colistin methanesulfonate, intrathecal for 24 days and intravenous for 46 days. In addition, the patient received meropenem and teicoplanin to treat a urinary tract infection and a bacterial aspiration pneumonia. Cerebrospinal fluid trough colistin levels resulted above the MIC of A. baumannii. Colistin cerebrospinal fluid concentration did not increase over the treatment period. Meningitis was cured and A. baumannii eradicated. No side effects from the antimicrobial therapy were observed. In conclusion, this case highlights the issues in treating infections caused by resistant Gram negative bacteria and supports previous findings on the efficacy, pharmacokinetic and tolerability of intravenous and intrathecal colistin treatments.

• Authors: Elisabetta Schiaroli, Maria Bruna Pasticci, Maria Iris Cassetta, Stefania Fallani, Corrado Castrioto, Matteo Pirro, Andrea Novelli, Lucia Henrici De Angelis, Marco Maria D'Andrea, Maria Lina Mezzatesta, Franco Baldelli, Antonella Mencacci
• Journal: Mediterranean journal of hematology and infectious diseases (Mediterr J Hematol Infect Dis) Vol. 7 Issue 1 Pg. e2015055 ( 2015) ISSN: 2035-3006 [Print] Italy
• PMID: 26543524 (Publication Type: Case Reports)