Abstract | OBJECTIVE: APPROACH AND RESULTS: We measured cholesterol efflux capacity in 227 patients with heterozygous FH under pharmaceutical treatment. Seventy-six (33.5%) of them were known to have ASCVD. In a logistic-regression analysis adjusted for risk factors, increased efflux capacity was associated with decreased risk of ASCVD even after the addition of high-density lipoprotein cholesterol level as a covariate (odds ratio per 1-SD increase, 0.95; 95% confidence interval, 0.90-0.99; P<0.05). Decreased cholesterol efflux capacity was associated with the presence of corneal arcus after adjusting for age and sex. In addition, inverse relationships between cholesterol efflux capacity and Achilles tendon thickness, as well as carotid intima-media thickness, were observed after adjustment for age, sex, and traditional cardiovascular risk factors. CONCLUSIONS:
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Authors | Masatsune Ogura, Mika Hori, Mariko Harada-Shiba |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 36
Issue 1
Pg. 181-8
(Jan 2016)
ISSN: 1524-4636 [Electronic] United States |
PMID | 26543100
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 American Heart Association, Inc. |
Chemical References |
- Biomarkers
- Cholesterol, HDL
- LDLR protein, human
- Receptors, LDL
- PCSK9 protein, human
- Proprotein Convertase 9
- Proprotein Convertases
- Serine Endopeptidases
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Topics |
- Achilles Tendon
(diagnostic imaging)
- Adult
- Aged
- Arcus Senilis
(blood, etiology, genetics)
- Asymptomatic Diseases
- Atherosclerosis
(blood, diagnosis, etiology, genetics)
- Biomarkers
(blood)
- Carotid Artery Diseases
(blood, etiology, genetics)
- Carotid Intima-Media Thickness
- Cholesterol, HDL
(blood)
- Cross-Sectional Studies
- Female
- Genetic Predisposition to Disease
- Heterozygote
- Humans
- Hyperlipoproteinemia Type II
(blood, diagnosis, genetics)
- Linear Models
- Logistic Models
- Male
- Middle Aged
- Mutation
- Odds Ratio
- Phenotype
- Proprotein Convertase 9
- Proprotein Convertases
(genetics)
- Radiography
- Receptors, LDL
(genetics)
- Serine Endopeptidases
(genetics)
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