Abstract |
We conducted a randomized open-labeled study of nifedipine versus propranolol for the initial prophylaxis of migraine. Propranolol was effective in 67% of patients (12/18) and well tolerated. Nifedipine was effective in only 30% of patients (6/20). The lack of overall efficacy of nifedipine was attributable to a high incidence of side effects, including an unusual symptom complex resembling erythromelalgia. These side effects led 45% (9/20) of the nifedipine patients to withdraw from the study within two weeks. By contrast, no patient (0/18) withdrew from the study within the first 2 weeks of propranolol therapy. We conclude that nifedipine is not an agent of first choice for the prophylaxis of migraine.
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Authors | G W Albers, L T Simon, A Hamik, S J Peroutka |
Journal | Headache
(Headache)
Vol. 29
Issue 4
Pg. 215-8
(Apr 1989)
ISSN: 0017-8748 [Print] United States |
PMID | 2654067
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Adult
- Clinical Trials as Topic
- Female
- Humans
- Male
- Middle Aged
- Migraine Disorders
(prevention & control)
- Nifedipine
(adverse effects, therapeutic use)
- Propranolol
(adverse effects, therapeutic use)
- Random Allocation
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