HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Nifedipine versus propranolol for the initial prophylaxis of migraine.

Abstract
We conducted a randomized open-labeled study of nifedipine versus propranolol for the initial prophylaxis of migraine. Propranolol was effective in 67% of patients (12/18) and well tolerated. Nifedipine was effective in only 30% of patients (6/20). The lack of overall efficacy of nifedipine was attributable to a high incidence of side effects, including an unusual symptom complex resembling erythromelalgia. These side effects led 45% (9/20) of the nifedipine patients to withdraw from the study within two weeks. By contrast, no patient (0/18) withdrew from the study within the first 2 weeks of propranolol therapy. We conclude that nifedipine is not an agent of first choice for the prophylaxis of migraine.
AuthorsG W Albers, L T Simon, A Hamik, S J Peroutka
JournalHeadache (Headache) Vol. 29 Issue 4 Pg. 215-8 (Apr 1989) ISSN: 0017-8748 [Print] United States
PMID2654067 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Propranolol
  • Nifedipine
Topics
  • Adult
  • Clinical Trials as Topic
  • Female
  • Humans
  • Male
  • Middle Aged
  • Migraine Disorders (prevention & control)
  • Nifedipine (adverse effects, therapeutic use)
  • Propranolol (adverse effects, therapeutic use)
  • Random Allocation

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: