Abstract | OBJECTIVES: METHODS: We conducted a retrospective analysis of data collected in Esmeraldas (Ecuador) during surveys conducted in areas where ivermectin was annually administered to the entire population for the control of onchocerciasis. Data from 5 surveys, conducted between 1990 (before the start of the distribution of ivermectin) and 2013 (six years after the interruption of the intervention) were analyzed. The surveys also comprised areas where ivermectin was not distributed because onchocerciasis was not endemic. Different laboratory techniques were used in the different surveys (direct fecal smear, formol- ether concentration, IFAT and IVD ELISA for Strongyloides stercoralis). RESULTS: In the areas where ivermectin was distributed the strongyloidiasis prevalence fell from 6.8% in 1990 to zero in 1996 and 1999. In 2013 prevalence in children was zero with stool examination and 1.3% with serology, in adult 0.7% and 2.7%. In areas not covered by ivermectin distribution the prevalence was 23.5% and 16.1% in 1996 and 1999, respectively. In 2013 the prevalence was 0.6% with fecal exam and 9.3% with serology in children and 2.3% and 17.9% in adults. Regarding other soil transmitted helminthiases: in areas where ivermectin was distributed the prevalence of T. trichiura was significantly reduced, while A. lumbricoides and hookworms were seemingly unaffected. CONCLUSIONS:
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Authors | Mariella Anselmi, Dora Buonfrate, Angel Guevara Espinoza, Rosanna Prandi, Monica Marquez, Maria Gobbo, Antonio Montresor, Marco Albonico, Marcia Racines Orbe, Juan Martin Moreira, Zeno Bisoffi |
Journal | PLoS neglected tropical diseases
(PLoS Negl Trop Dis)
Vol. 9
Issue 11
Pg. e0004150
(Nov 2015)
ISSN: 1935-2735 [Electronic] United States |
PMID | 26540412
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Animals
- Anthelmintics
(therapeutic use)
- Ascariasis
(epidemiology)
- Child
- Child, Preschool
- Drug Therapy
(methods)
- Ecuador
(epidemiology)
- Female
- Hookworm Infections
(epidemiology)
- Humans
- Ivermectin
(therapeutic use)
- Male
- Middle Aged
- Onchocerciasis
(drug therapy)
- Prevalence
- Retrospective Studies
- Strongyloides stercoralis
(drug effects)
- Strongyloidiasis
(epidemiology)
- Trichuriasis
(epidemiology)
- Young Adult
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