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Paraneoplastic syndrome-associated neuronal antibodies in adult ADHD.

Abstract
A high seroprevalence of Yo antibodies targeting cerebellar Purkinje cells was recently reported in children with attention deficit/hyperactivity disorder (ADHD). We investigated the presence of 8 paraneoplastic neurological syndrome (PNS)-associated antibodies including anti-Yo in 169 adult ADHD patients. No associations between ADHD and serum Yo antibodies or other antibodies associated with PNS were found. However, 10 out of 48 ADHD patient sera analyzed by immunofluorescence presented antibodies targeting cerebellar Purkinje cells. This reactivity probably represents the presence of low levels of antibodies against multiple cellular hitherto unknown antigens with little to no clinical significance.
AuthorsBjørn Ivar Haukanes, Tor-Arne Hegvik, Tilo Eichler, Jan Haavik, Christian Vedeler
JournalJournal of neuroimmunology (J Neuroimmunol) Vol. 288 Pg. 87-91 (Nov 15 2015) ISSN: 1872-8421 [Electronic] Netherlands
PMID26531699 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.
Chemical References
  • Autoantibodies
Topics
  • Adolescent
  • Adult
  • Animals
  • Attention Deficit Disorder with Hyperactivity (blood, immunology)
  • Autoantibodies (blood)
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Immunoblotting
  • Male
  • Middle Aged
  • Neurons (immunology)
  • Rats
  • Young Adult

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