Abstract | BACKGROUND: METHODS: RESULTS: In the GC-MS analysis 141 and 122 compounds were indentified in Ph.LO and Ph.FO respectively. Caryophylene oxide (41.42 %) was the major component in Ph.FO while decahydronaphthalene (38.29 %) was prominent in Ph.LO. In AChE inhibition, Ph.LO and Ph.FO exhibited 87.00** and 79.66***% inhibitions at 1000 μg/ml with IC50 of 120 and 220 μg/ml respectively. The IC50 value for galanthamine was 15 μg/ml. In BChE inhibitory assay, Ph.LO and Ph.FO caused 82.66*** (IC50 130 μg/ml) and 77.50***% (IC50 225 μg/ml) inhibitions respectively at 1000 μg/ml concentration. In DPPH free radical scavenging assay, Ph.LO and Ph.FO exhibited IC50 of 20 and 200 μg/ml respectively. The calculated IC50s were 180 & 60 μg/ml for Ph.LO, and 45 & 50 μg/ml for Ph.FO in scavenging of ABTS and H2O2 free radicals respectively. CONCLUSIONS:
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Authors | Muhammad Ayaz, Muhammad Junaid, Farhat Ullah, Abdul Sadiq, Mir Azam Khan, Waqar Ahmad, Muhammad Raza Shah, Muhammad Imran, Sajjad Ahmad |
Journal | Lipids in health and disease
(Lipids Health Dis)
Vol. 14
Pg. 141
(Nov 04 2015)
ISSN: 1476-511X [Electronic] England |
PMID | 26530857
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Benzothiazoles
- Biphenyl Compounds
- Cholinesterase Inhibitors
- Free Radical Scavengers
- Oils, Volatile
- Picrates
- Plant Extracts
- Sulfonic Acids
- 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
- Hydrogen Peroxide
- 1,1-diphenyl-2-picrylhydrazyl
- Acetylcholinesterase
- Butyrylcholinesterase
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Topics |
- Acetylcholinesterase
(chemistry, isolation & purification)
- Animals
- Benzothiazoles
(antagonists & inhibitors, chemistry)
- Biphenyl Compounds
(antagonists & inhibitors, chemistry)
- Butyrylcholinesterase
(chemistry, isolation & purification)
- Cholinesterase Inhibitors
(chemistry, isolation & purification)
- Electrophorus
- Enzyme Assays
- Flowers
(chemistry)
- Free Radical Scavengers
(chemistry, isolation & purification)
- Gas Chromatography-Mass Spectrometry
- Horses
- Hydrogen Peroxide
(chemistry)
- Oils, Volatile
(chemistry, isolation & purification)
- Picrates
(antagonists & inhibitors, chemistry)
- Plant Extracts
(chemistry)
- Plant Leaves
(chemistry)
- Polygonum
(chemistry)
- Sulfonic Acids
(antagonists & inhibitors, chemistry)
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