Estimation of Osteoblastic Functions by Biological Bone Markers.

Abstract

The purpose of this study is to identify the lowest value ofNMID osteocalcin and PINP when CTx is below or equal to 0.10 ng/ml at which neither bone formation nor bone resorption occurs. This may be harmful to bone texture. The 223 cases of CTx equal or below 0.100 ng/ml of CTx were enrolled. They consisted of 42 cases or 18.83% of menopausal women, 110 cases or 49.32% ofpost anti-resorptive therapy, 22 cases or 9.8% elderly and 49 cases or 21.97% unknown causes. The results show PINP = 15.88 ng/ml and NMID osteocalcin = 10.81 ng/ml. We used them as a cut value for diagnosis of bone condition. The benefits of this study: helping the physician in the treatment of bone diseases, osteoporosis in cases of over treatment, when the value of CTx is below or above 0.1 ng/ml or 0.01-0.099 ng/ml; when there is no bone resorption and osteoblastic function is poor if the values of NMID osteocalcin or PINP are still equal to 10.81, 15.88 ng/ml at any level of BetacrossLap, respectively.

• Authors: Narong Bunyaratavej
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 98 Suppl 8 Pg. S5-7 (Sep 2015) ISSN: 0125-2208 [Print] Thailand
• PMID: 26529806 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Collagen Type I
• Peptide Fragments
• Peptides
• Procollagen
• collagen type I trimeric cross-linked peptide
• procollagen Type I N-terminal peptide
• Osteocalcin

Topics

• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Collagen Type I (blood)
• Female
• Humans
• Middle Aged
• Osteoblasts (physiology)
• Osteocalcin (blood)
• Peptide Fragments (blood)
• Peptides (blood)
• Procollagen (blood)