Castleman Disease. A Report of Six Cases.

Abstract

BACKGROUND AND AIMS:

Castleman's disease is a rare disorder situated at the boundary between reactive and neoplastic conditions. The pathogenesis is a subject of debate and the limited number of cases renders the study of the disease difficult. In our paper we present a series of six cases of Castleman disease with emphasis on the clinical presentation, pathology examination and the use of immunohistochemistry in the final diagnosis of the cases.

PATIENTS AND METHOD:

The classification of the disease was based on clinical, imaging and pathological assessment. Specimens were obtained by surgical excision and were routinely processed for the pathology examination.

RESULTS:

All cases were unicentric disease. Two cases were locally extensive. The clinical symptoms were related mostly to compression effects. Five case were of the hyaline-vascular type and one was included in the plasma cell variant. One case showed angiomyoid differentiation.

CONCLUSIONS:

We strongly believe that by understanding the pathogenesis of the precursor lesions we will gain better understanding of the pathways that lead to neoplasia and that Castleman disesase is a very interesting "natural experiment" illustrating the progression from chronic antigen stimulation to reactive lymphoid hyperplasia and finally to overt lymphoid neoplasia.

• Authors: Bogdan Fetica, Bogdan Pop, Cosmin Lisencu, Alin Cristian Rancea, Aurel Coman, Andrei Cucuianu, Ljubomir Petrov
• Journal: Clujul medical (1957) (Clujul Med) Vol. 87 Issue 3 Pg. 192-7 ( 2014) ISSN: 1222-2119 [Print] Romania
• PMID: 26528023 (Publication Type: Case Reports)