Abstract | PURPOSE: PATIENTS AND METHODS: RESULTS: We recruited 289 patients with localized CRC (173 received chemotherapy; median age, 59 years; 63% male), 73 patients with limited metastatic/recurrent CRC, and 72 HCs. Cognitive impairment was more frequent in patients with localized CRC than HCs at baseline (43% v 15%, respectively; P < .001) and 12 months (46% v 13%, respectively; P < .001), with no significant effect of chemotherapy. Attention/working memory, verbal learning/memory, and complex processing speed were most affected. Cognitive impairment was similar in patients with localized and metastatic CRC. Cytokine levels were elevated in patients with CRC compared with HCs. There was no association between overall cognitive function and fatigue, quality of life, anxiety/depression, or any blood test. Cognitive symptoms at 12 months were reported in 25% of patients with localized CRC versus 17% of HCs (P = .19). More participants who received chemotherapy had cognitive symptoms at 6 months (32%) versus those who did not (16%; P = .007), with no significant difference at 12 months (29% v 21%, respectively; P = .19). Objective cognitive function was only weakly associated with cognitive symptoms. CONCLUSION:
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Authors | Janette L Vardy, Haryana M Dhillon, Gregory R Pond, Sean B Rourke, Tsegaye Bekele, Corrinne Renton, Anna Dodd, Haibo Zhang, Philip Beale, Stephen Clarke, Ian F Tannock |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 33
Issue 34
Pg. 4085-92
(Dec 01 2015)
ISSN: 1527-7755 [Electronic] United States |
PMID | 26527785
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 by American Society of Clinical Oncology. |
Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects)
- Case-Control Studies
- Cognition
(drug effects)
- Cognition Disorders
(chemically induced)
- Colorectal Neoplasms
(drug therapy, pathology)
- Fatigue
(chemically induced)
- Female
- Follow-Up Studies
- Humans
- Longitudinal Studies
- Lymphatic Metastasis
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(drug therapy, pathology)
- Neoplasm Staging
- Neuropsychological Tests
- Prognosis
- Prospective Studies
- Quality of Life
- Surveys and Questionnaires
- Young Adult
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