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Ethyl acetate Salix alba leaves extract-loaded chitosan-based hydrogel film for wound dressing applications.

Abstract
High toxicity and multidrug resistance associated with various standard antimicrobial drugs have necessitated search for safer alternatives in plant-derived materials. In this study, we performed biological examination of chitosan-based hydrogel film loaded with ethyl acetate Salix alba leaves extract against 11 standard laboratory strains. FTIR showed regeneration of saccharide peak in CP1A at 1047 cm(-1) and increased in height of other peaks. DSC exothermic decomposition peaks at 112 °C, 175 °C and 251 °C reveal the effect of extract on hydrogel film. From FESEM images, three-dimensional cross-linking and extract easily seen in the globular form from the surface. MTT assay on HEK 293 cells showed that CP1A was non-toxic. Minimum inhibitory concentration ranges from 4000 μg/ml to 125 μg/ml. Enterococcus faecium, Candida glabrata and Candida tropicalis were the most resistant, while Salmonella typhi and Candida guilliermondii were the most susceptible micro-organisms.
AuthorsMohammad A Qureshi, Fehmeeda Khatoon, Moshahid A Rizvi, Md Zafaryab
JournalJournal of biomaterials science. Polymer edition (J Biomater Sci Polym Ed) Vol. 26 Issue 18 Pg. 1452-64 ( 2015) ISSN: 1568-5624 [Electronic] England
PMID26525493 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Acetates
  • Anti-Bacterial Agents
  • Methylgalactosides
  • Plant Extracts
  • hydrogel film
  • ethyl acetate
  • Chitosan
Topics
  • Acetates (chemistry)
  • Anti-Bacterial Agents (administration & dosage)
  • Bandages, Hydrocolloid
  • Candida (drug effects)
  • Candida glabrata (drug effects)
  • Candida tropicalis (drug effects)
  • Chitosan (chemistry)
  • Enterococcus faecium (drug effects)
  • HEK293 Cells
  • Humans
  • Materials Testing
  • Methylgalactosides (chemistry)
  • Microbial Sensitivity Tests
  • Plant Extracts (administration & dosage, chemistry)
  • Plant Leaves (chemistry)
  • Salix
  • Salmonella typhi (drug effects)
  • Surface Properties

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