Abstract |
High toxicity and multidrug resistance associated with various standard antimicrobial drugs have necessitated search for safer alternatives in plant-derived materials. In this study, we performed biological examination of chitosan-based hydrogel film loaded with ethyl acetate Salix alba leaves extract against 11 standard laboratory strains. FTIR showed regeneration of saccharide peak in CP1A at 1047 cm(-1) and increased in height of other peaks. DSC exothermic decomposition peaks at 112 °C, 175 °C and 251 °C reveal the effect of extract on hydrogel film. From FESEM images, three-dimensional cross-linking and extract easily seen in the globular form from the surface. MTT assay on HEK 293 cells showed that CP1A was non-toxic. Minimum inhibitory concentration ranges from 4000 μg/ml to 125 μg/ml. Enterococcus faecium, Candida glabrata and Candida tropicalis were the most resistant, while Salmonella typhi and Candida guilliermondii were the most susceptible micro-organisms.
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Authors | Mohammad A Qureshi, Fehmeeda Khatoon, Moshahid A Rizvi, Md Zafaryab |
Journal | Journal of biomaterials science. Polymer edition
(J Biomater Sci Polym Ed)
Vol. 26
Issue 18
Pg. 1452-64
( 2015)
ISSN: 1568-5624 [Electronic] England |
PMID | 26525493
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acetates
- Anti-Bacterial Agents
- Methylgalactosides
- Plant Extracts
- hydrogel film
- ethyl acetate
- Chitosan
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Topics |
- Acetates
(chemistry)
- Anti-Bacterial Agents
(administration & dosage)
- Bandages, Hydrocolloid
- Candida
(drug effects)
- Candida glabrata
(drug effects)
- Candida tropicalis
(drug effects)
- Chitosan
(chemistry)
- Enterococcus faecium
(drug effects)
- HEK293 Cells
- Humans
- Materials Testing
- Methylgalactosides
(chemistry)
- Microbial Sensitivity Tests
- Plant Extracts
(administration & dosage, chemistry)
- Plant Leaves
(chemistry)
- Salix
- Salmonella typhi
(drug effects)
- Surface Properties
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