Abstract | INTRODUCTION:
Ivabradine has opened up new possibilities for treating stable angina and chronic heart failure by lowering heart rate. Ivabradine lowers heart rate by selectively inhibiting the I f current in the sinoatrial node. This study aimed to determine whether the decrease in heart rate achieved with ivabradine was accompanied by hemodynamic changes that might lead to an enhancement of endothelial function. METHODS: Thirty patients with stable angina pectoris were included in the study. Ivabradine (5 mg bid) was added to the recommended standard treatment. Endothelial function was assessed at baseline and after 3 months of ivabradine therapy, with an Endo-PAT 2000 device (Itamar Medical, Israel). This device was recently developed for the noninvasive assessment for endothelial dysfunction. We evaluated reactive hyperemia index (RHI), which reflects endothelial function, and augmentation index (AI), which provides an indication of arterial stiffness. RESULTS: CONCLUSION: The addition of ivabradine to the treatment regimen of patients with stable angina pectoris both lowered heart rate and improved endothelial function. However, broader, randomized, double-blind, placebo-controlled clinical trials are required to confirm these findings.
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Authors | Lucia Jedlickova, Lucia Merkovska, Lucia Jackova, Martin Janicko, Jan Fedacko, Bozena Novakova, Anna Chmelarova, Jaroslav Majernik, Daniel Pella |
Journal | Advances in therapy
(Adv Ther)
Vol. 32
Issue 10
Pg. 962-70
(Oct 2015)
ISSN: 1865-8652 [Electronic] United States |
PMID | 26525390
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzazepines
- Cardiovascular Agents
- Ivabradine
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Topics |
- Aged
- Angina, Stable
(drug therapy)
- Benzazepines
(pharmacology)
- Cardiovascular Agents
(therapeutic use)
- Drug Therapy, Combination
- Endothelium, Vascular
(drug effects)
- Female
- Heart Failure
(drug therapy)
- Heart Rate
(drug effects)
- Hemodynamics
(drug effects)
- Humans
- Ivabradine
- Male
- Middle Aged
- Sinoatrial Node
(drug effects)
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