To investigate the effect of
Butylphthalide and
Xue Shuan Tong on serum inflammatory factors and prognosis of patients with
cerebral infarction. One hundred and twenty patients with acute
cerebral infarction were randomly divided into control group,
Butylphthalide group and
Xue Shuan Tong group, with 40 patients in each group. Conventional
therapy was performed in the control group; On the basis of conventional
therapy, 100ml
Butylphthalide intravenously twice a day was administrated among patients in
Butylphthalide group; On the basis of conventional
therapy, 250ml
0.9% NaCl intravenously once a day was conducted among patients in
Xue Shuan Tong group. A treatment course of continuous 7 days was taken in the three groups. The serum levels of
IL-2 and CGRP were detected for patients in the three groups before and
after treatment. Carotid plaque thickness and size as well as intima-media thickness were detected by ultrasonic testing for patients in three groups before treatment and 90 days after follow-up. The NIHSS, Barthel and MRS scoring were performed for all the patients after 90-day follow-up to evaluate the prognosis.
After treatment, differences in the levels of
IL-2 and CGRP for patients in the three groups showed statistical significance (P<0.05), while the levels of
IL-2 and CGRP in
Xue Shuan Tong group were significantly higher than those in the other two groups (P<0.05). After 7-day treatment, plaque size and thickness in
Xue Shuan Tong group and
Butylphthalide group were significantly reduced, compared with those before treatment (P<0.05), but no significant differences was shown in the plaque size and thickness between
Xue Shuan Tong group and
Butylphthalide group (P>0.05) .The CA-IMT in
Xue Shuan Tong group and
Butylphthalide group was significantly reduced
after treatment, and that in
Butylphthalide group was significantly larger than that in
Xue Shuan Tong group (P<0.05). After 90-day follow-up, NIHSS scores in
Butylphthalide group were significantly less than those in the other two groups (P<0.05). After 90-day follow-up, Barthel scores in
Butylphthalide group and
Xue Shuan Tong group were significantly larger than those in control group (P<0.05), while differences between
Butylphthalide group and
Xue Shuan Tong group indicated no statistical significance (P>0.05). There were significant differences in MRS scores among patients in the three groups after 90-day follow-up (P<0.05).
Butylphthalide and
Xue Shuan Tong are clinically effective in treating acute
cerebral infarction.
Butylphthalide has significant efficacy in inhibiting
inflammation and improving prognosis of neurological function, while
Xue Shuan Tong has obvious effect in improving carotid intima-media thickness.