Effects of Inhibitors of Necroptosis and Autophagy on Morphofunctional Characteristics of the Myocardium during Static Cold Storage of Donor Rat Heart.

Abstract	Cardioprotective effects of necrostatin-1 (necroptosis inhibitor) and 3-methyladenine (autophagy inhibitor) were studied on the model of long-term cold preservation of rat heart. Addition of necrostatin-1 (490 nmol/liter) or 3-methyladenine (4.5 mmol/liter) to custodiol preserving solution reduced myocardial infarction size and improved left-ventricular function during reperfusion after 8-h preservation at 4°C. Inhibition of necroptosis and autophagy contributed to the cardioprotective effect under conditions of cold preservation of the donor heart.
Authors	Yu V Dmitriev, S M Minasyan, L V Vasina, E A Demchenko, M M Galagudza
Journal	Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 159 Issue 6 Pg. 792-5 (Oct 2015) ISSN: 1573-8221 [Electronic] United States
PMID	26519272 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Bretschneider cardioplegic solution Cardiotonic Agents Imidazoles Indoles necrostatin-1 Mannitol Procaine Potassium Chloride Glucose
Topics	Animals Autophagy (drug effects) Cardiotonic Agents (pharmacology) Cold Temperature Cryopreservation Glucose (pharmacology) Heart (drug effects) Imidazoles (pharmacology) Indoles (pharmacology) Male Mannitol (pharmacology) Myocardium (pathology) Necrosis Organ Size Potassium Chloride (pharmacology) Procaine (pharmacology) Rats Rats, Wistar Tissue Donors Tissue Preservation (methods)

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