Ciprofloxacin for the treatment of chronic ear disease.

Abstract

The treatment of chronic ear disease is often difficult and frustrating. Patients typically present with a history of chronic, persistent otorrhea that has failed to respond to multiple topical and oral antibiotics. Organisms that are resistant to multiple antibiotics are common. Ciprofloxacin has been shown to be effective against a wide range of gram-negative and gram-positive organisms. To evaluate the role of ciprofloxacin in the treatment of chronic ear disease, 21 patients who failed routine therapy for chronic ear disease were prospectively treated with oral ciprofloxacin. Prior to therapy, all ear cultures grew Pseudomonas aeruginosa, Staphylococcus aureus or other gram-negative organisms. Ninety-five percent of patients completing therapy showed either improvement or cure. Only one patient failed to improve. Ciprofloxacin has been shown to be effective in the management of chronic ear disease.

• Authors: J F Piccirillo, S M Parnes
• Journal: The Laryngoscope (Laryngoscope) Vol. 99 Issue 5 Pg. 510-3 (May 1989) ISSN: 0023-852X [Print] United States
• PMID: 2651829 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Ciprofloxacin

Topics

• Adult
• Aged
• Cholesteatoma (drug therapy)
• Chronic Disease
• Ciprofloxacin (therapeutic use)
• Clinical Trials as Topic
• Female
• Humans
• Male
• Mastoiditis (drug therapy)
• Middle Aged
• Otitis (drug therapy)
• Otitis Externa (drug therapy)
• Prospective Studies
• Pseudomonas Infections (drug therapy)
• Staphylococcal Infections (drug therapy)