Results of a multicenter outpatient burn study on the safety and efficacy of Dimac-SSD, a new delivery system for silver sulfadiazine.

Abstract

Dimac with silver sulfadiazine (Dimac-SSD), a new silver sulfadiazine delivery system, was evaluated prospectively in a multicenter study for the treatment of outpatient burn injuries. The goal of this study was to evaluate the effect of Dimac-SSD on the microbiology of the burn wounds and to quantitate its clinical safety and efficacy. A total of 197 patients were evaluated. Eight (4%) of these patients did not complete the study. Six patients withdrew because of local discomfort caused by the Dimac-SSD and two patients were terminated because of technical problems. The mean +/- SD duration of treatment with Dimac-SSD was 12 +/- 8.5 days, during which time the mean number of dressing changes was 2.9 per patient. During treatment with Dimac-SSD, the burn wound bacterial flora remained stable and overgrowth with Pseudomonas species or Gram-negative bacilli did not occur. Only four (2%) patients developed clinical infections; thus the Dimac-SSD appeared to have good antimicrobial effectiveness. This dressing was not associated with any organ system or metabolic side-effects and patient discomfort during application and removal was minimal. Thus this new delivery system for silver sulfadiazine was associated with excellent wound healing, a low incidence of wound infections, reduced frequency for dressing changes, and excellent patient compliance.

• Authors: E A Deitch, K Sittig, D Heimbach, M Jordan, W Cruse, A Kahn, B Achauer, R Finley, T Matsuda, R Salisbury
• Journal: The Journal of trauma (J Trauma) Vol. 29 Issue 4 Pg. 430-4 (Apr 1989) ISSN: 0022-5282 [Print] United States
• PMID: 2651681 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Acrylates
• Dimac-SSD
• Drug Combinations
• Methacrylates
• Sulfadiazine
• Silver
• Polyethylene Glycols
• Silver Sulfadiazine
• Dimethyl Sulfoxide

Topics

• Acrylates (administration & dosage)
• Administration, Cutaneous
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Ambulatory Care
• Bandages
• Burns (microbiology, therapy)
• Child
• Child, Preschool
• Dimethyl Sulfoxide (administration & dosage, blood)
• Drug Combinations (administration & dosage)
• Evaluation Studies as Topic
• Female
• Humans
• Male
• Methacrylates (administration & dosage)
• Middle Aged
• Multicenter Studies as Topic
• Polyethylene Glycols (administration & dosage)
• Prospective Studies
• Silver (blood)
• Silver Sulfadiazine (administration & dosage)
• Sulfadiazine (administration & dosage, blood)
• Wound Infection (prevention & control)