Ticlopidine-pentoxifylline combination in the treatment of atherosclerosis and the prevention of cerebrovascular accidents.

Abstract

This randomized, double-blind study on 79 patients reported the efficacy of ticlopidine-pentoxifylline combination in the treatment of atherosclerosis and the prevention of cerebrovascular accidents. Comparisons were made with aspirin-dipyridamole-buflomedil and buflomedil-placebo combinations as controls. Global symptoms, sensorimotor disorders and vertigo were improved in all treatment groups, although improvement tended to be more pronounced with ticlopidine-pentoxifylline. None of the groups showed any change in stenosis or vessel wall rigidity although ticlopidine-pentoxifylline reduced flow irregularity. This combination therapy also normalized the direction of flow in the ophthalmic artery in 46.2% of patients with retrograde flow prior to treatment, compared with 30.0% following aspirin-dipyridamole-buflomedil and 28.6% following buflomedil-placebo administration. Significantly fewer cerebrovascular accidents occurred after treatment with ticlopidine-pentoxifylline. In conclusion, ticlopidine-pentoxifylline showed good therapeutic efficacy against atherosclerosis and a preventative effect against new cerebrovascular accidents. This therapy was well tolerated.

• Authors: A Apollonio, P Castignani, L Magrini, R Angeletti
• Journal: The Journal of international medical research (J Int Med Res) 1989 Jan-Feb Vol. 17 Issue 1 Pg. 28-35 ISSN: 0300-0605 [Print] England
• PMID: 2651175 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Pyrrolidines
• Vasodilator Agents
• Dipyridamole
• Theobromine
• Ticlopidine
• Aspirin
• Pentoxifylline
• buflomedil

Topics

• Arteriosclerosis (complications, drug therapy)
• Aspirin (therapeutic use)
• Cerebrovascular Disorders (prevention & control)
• Clinical Trials as Topic
• Dipyridamole (therapeutic use)
• Double-Blind Method
• Drug Therapy, Combination
• Female
• Humans
• Male
• Middle Aged
• Pentoxifylline (therapeutic use)
• Pyrrolidines (therapeutic use)
• Random Allocation
• Theobromine (analogs & derivatives)
• Ticlopidine (therapeutic use)
• Vasodilator Agents (therapeutic use)