Cyclin D1 in pediatric neuroblastic tumors: A microarray analysis.

Abstract

Neuroblastoma is the most common extracranial solid childhood tumor, which is believed to originate from primitive neuroblasts giving rise to the sympathetic nervous system. It was previously shown that cyclin D1 (CCDN1) in pediatric neuroblastic tumors (neuroblastoma, ganglioneuroblastoma, and ganglioneuroma) recapitulates its expression during the development of peripheral sympathetic nervous system (PSNS). In the present study, we performed a microarray analysis in order to evaluate the expression of cyclin D1 in neuroblastoma as compared to ganglioneuroma and ganglioneuroblastoma. We first confirmed that comparable levels of cyclin D1 are present in neuroblastoma and fetal neuroblasts. In addition, we observed that neuroblastoma is associated to significantly higher levels of cyclin D1 as compared to both ganglioneuroma and ganglioneuroblastoma. No differences are instead observable between ganglioneuroblastoma and ganglioneuroma. Finally, bioinformatic analysis of cyclin D1-functionally related genes, identified cyclin D2 as an additional marker/etiopathogenic factor in the development of neuroblastoma.

• Authors: Paolo Fagone, Ferdinando Nicoletti, Giada Maria Vecchio, Rosalba Parenti, Gaetano Magro
• Journal: Acta histochemica (Acta Histochem) Vol. 117 Issue 8 Pg. 820-3 (Oct 2015) ISSN: 1618-0372 [Electronic] Germany
• PMID: 26510683 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier GmbH. All rights reserved.

Chemical References

• Biomarkers, Tumor
• CCND1 protein, human
• Cyclin D1

Topics

• Biomarkers, Tumor (genetics, metabolism)
• Child
• Cyclin D1 (genetics, metabolism)
• Ganglioneuroblastoma (metabolism, pathology)
• Ganglioneuroma (metabolism, pathology)
• Gene Expression
• Humans
• Neuroblastoma (metabolism, pathology)
• Oligonucleotide Array Sequence Analysis