Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in patients with familial Mediterranean fever.

Abstract

BACKGROUND/AIMS:

Serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) are well-known inflammatory biomarkers, with a diagnostic potential for various diseases. The aim of the present study was to determine the potential diagnostic applications of serum MMP-9 and TIMP-1 concentrations in patients with familial Mediterranean fever (FMF).

MATERIALS AND METHODS:

A total of 66 male FMF patients and 40 age-matched healthy subjects were included in this research. TIMP-1 and MMP-9 levels with conventional inflammation markers were determined. Pearson correlation analysis was used to determine the correlation between the characteristics of patients and the laboratory data.

RESULTS:

In patients with FMF, serum MMP-9 levels and MMP-9/TIMP-1 ratios were found to be significantly elevated in both acute episode and asymptomatic periods (p=0.0001 and p=0.0001, respectively). There was no significant difference between TIMP-1 levels. A significant negative correlation between patients' current age and TIMP-1 level in patients with acute episodes was detected (p=0.0008, r=-0.52). Moreover, a moderate negative correlation was noticed between erythrocyte sedimentation rate and TIMP-1 level in patients with acute episodes (p=0.01, r=-0.39). Additionally, a moderate negative correlation was found between the duration of colchicine use and MMP-9 and TIMP-1 levels during the attack period (p=0.04, r=-0.36 and p=0.02, r=-0.39, respectively).

CONCLUSION:

Our findings demonstrate that a significant MMP-9/TIMP-1 imbalance exists in patients with FMF, which reflects an ongoing inflammation in both FMF periods. Thus, the increased MMP-9 levels observed in FMF patients could rationalize therapeutic targeting to MMPs.

• Authors: Mustafa Dinç, Alpaslan Tanoğlu, Yusuf Yazgan, Yavuz Beyazıt, Kemal Öncü, Yalçın Önem, Serdar Hıra, Mustafa Kaplan, İrfan Küçük, Yusuf Serdar Sakın, Levent Demirtürk
• Journal: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology (Turk J Gastroenterol) Vol. 26 Issue 6 Pg. 487-91 (Nov 2015) ISSN: 2148-5607 [Electronic] Turkey
• PMID: 26510088 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Tissue Inhibitor of Metalloproteinase-1
• Tubulin Modulators
• MMP9 protein, human
• Matrix Metalloproteinase 9
• Colchicine

Topics

• Acute Disease
• Adult
• Age Factors
• Biomarkers (blood)
• Blood Sedimentation
• Case-Control Studies
• Colchicine (therapeutic use)
• Cross-Sectional Studies
• Familial Mediterranean Fever (blood, drug therapy)
• Female
• Humans
• Male
• Matrix Metalloproteinase 9 (blood)
• Tissue Inhibitor of Metalloproteinase-1 (blood)
• Tubulin Modulators (therapeutic use)
• Young Adult