A Facile Way for Fabricating PEGylated Hollow Mesoporous Silica Nanoparticles and Their Drug Delivery Application.

Abstract

PEGylated hollow mesoporous silica nanoparticles (HMSN-PEG) were successfully fabricated by only one simple step through hydrothermal treatment in Na2CO3 solution. HMSN-PEG nanoparticles were transformed from conventional PEG-modified mesoporous silica nanoparticles (MSN-PEG). The as-synthesized HMSN-PEG nanoparticles exhibited higher loading capacity of anticancer drug (Doxorubicin) and better sustained release property than MSN and MSN-PEG particles. In vitro cell viability of HMSN-PEG nanoparticles to Hep-G2 cells was evaluated. HMSN-PEG nanoparticles have little in vitro cytotoxicity up to a concentration of 500 μg/ml. Furthermore, the DOX-loaded HMSN-PEG nanoparticles exhibited higher cytotoxicity than the DOX-loaded MSN and MSN-PEG nanoparticles against Hep-G2 cells. Therefore, the HMSN-PEG nanoparticle that generated in this PEG protecting etching strategy is a promising nanocarrier toward its potential application for cancer therapy.

• Authors: Xu Teng, Shan Cheng, Ran Meng, Shuai Zheng, Longyan Yang, Qian Ma, Wenguo Jiang, Junqi He
• Journal: Journal of nanoscience and nanotechnology (J Nanosci Nanotechnol) Vol. 15 Issue 5 Pg. 3773-9 (May 2015) ISSN: 1533-4880 [Print] United States
• PMID: 26505004 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Carriers
• Silicon Dioxide
• Doxorubicin

Topics

• Cell Survival (drug effects)
• Doxorubicin (chemistry, pharmacology)
• Drug Carriers (chemistry, toxicity)
• Hep G2 Cells
• Humans
• Nanoparticles (chemistry, toxicity)
• Porosity
• Silicon Dioxide (chemistry, toxicity)