Secondhand Tobacco Smoke Exposure and Lung Adenocarcinoma In Situ/Minimally Invasive Adenocarcinoma (AIS/MIA).

Abstract

The aim of this study was to estimate the effect of exposure to secondhand tobacco smoke on the incidence of lung adenocarcinoma in situ/minimally invasive adenocarcinoma (AIS/MIA). Data from seven case-control studies participating in the International Lung Cancer Consortium (ILCCO) were pooled, resulting in 625 cases of AIS/MIA and 7,403 controls, of whom 170 cases and 3,035 controls were never smokers. Unconditional logistic regression was used to estimate adjusted ORs (ORadj) and 95% confidence intervals (CI), controlling for age, sex, race, smoking status (ever/never), and pack-years of smoking. Study center was included in the models as a random-effects intercept term. Ever versus never exposure to secondhand tobacco smoke was positively associated with AIS/MIA incidence in all subjects (ORadj = 1.48; 95% CI, 1.14-1.93) and in never smokers (ORadj = 1.45; 95% CI, 1.00-2.12). There was, however, appreciable heterogeneity of ORadj across studies (P = 0.01), and the pooled estimates were largely influenced by one large study (40% of all cases and 30% of all controls). These findings provide weak evidence for an effect of secondhand tobacco smoke exposure on AIS/MIA incidence. Further studies are needed to assess the impact of secondhand tobacco smoke exposure using the newly recommended classification of subtypes of lung adenocarcinoma.

• Authors: Claire H Kim, Yuan-Chin Amy Lee, Rayjean J Hung, Paolo Boffetta, Dong Xie, Jason A Wampfler, Michele L Cote, Shen-Chih Chang, Donatella Ugolini, Monica Neri, Loic Le Marchand, Ann G Schwartz, Hal Morgenstern, David C Christiani, Ping Yang, Zuo-Feng Zhang
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 24 Issue 12 Pg. 1902-6 (Dec 2015) ISSN: 1538-7755 [Electronic] United States
• PMID: 26503035 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: ©2015 American Association for Cancer Research.

Chemical References

• Tobacco Smoke Pollution

Topics

• Adenocarcinoma (epidemiology, etiology, pathology)
• Adenocarcinoma of Lung
• Aged
• Aged, 80 and over
• Case-Control Studies
• Female
• Humans
• Lung Neoplasms (epidemiology, etiology, pathology)
• Male
• Middle Aged
• Risk Factors
• Tobacco Smoke Pollution (adverse effects, statistics & numerical data)