Abstract | AIM: METHOD: We evaluated the influence of three common single-nucleotide polymorphisms (SNPs) of the TERT gene (rs2853669, rs2736100, rs2736098) on susceptibility to colorectal cancer in 104 patients and 135 controls in a Turkish population. RESULTS: We observed that rs2736098 was significantly associated with increased risk of colorectal cancer (OR = 2.53; 95% CI = 1.26-5.10; p = 0.008). On the other hand, rs2736100 and rs2853669 showed no association with colorectal cancer (p ≥ 0.128). CONCLUSION: These findings are the first results of TERT allele distributions in the Turkish population and also provide increased understanding with respect to colorectal cancer etiology.
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Authors | Ayse Tarbin Jannuzzi, Ecem Karaman, Ezgi Oztas, Hakan Teoman Yanar, Gül Özhan |
Journal | Genetic testing and molecular biomarkers
(Genet Test Mol Biomarkers)
Vol. 19
Issue 12
Pg. 692-7
(Dec 2015)
ISSN: 1945-0257 [Electronic] United States |
PMID | 26501986
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- TERT protein, human
- Telomerase
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Topics |
- Adult
- Colorectal Neoplasms
(enzymology, epidemiology, genetics)
- Genetic Predisposition to Disease
- Humans
- Middle Aged
- Polymorphism, Single Nucleotide
- Telomerase
(genetics)
- Turkey
(epidemiology)
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