A Standardized Extract of Rhus verniciflua Stokes Protects Wistar Rats Against Lipopolysaccharide-Induced Acute Inflammation.

Abstract	Rhus verniciflua stokes (RVS) (Anacardiaceae) has been traditionally used as a folk remedy for gastritis, several cancers, and various metabolic diseases. The present study evaluated the anti-inflammatory effect of RVS extract standardized to fustin content using lipopolysaccharide (LPS)-stimulated rats. The rats were randomly divided into six groups and intragastrically administered 0, 100, 250, or 500 mg/kg body weight (bw) of RVS or 15 mg/kg bw of fustin for 14 days. LPS was intraperitoneally injected 18 h before sacrifice. The nitric oxide levels of RVS extract in either the serum or liver were significantly decreased compared to the LPS-treated rats (P<.05). The treatment with the RVS extract also blunted the rise of malondialdehyde levels in the liver (P<.05). The administration of RVS extract and fustin significantly prevented the elevation of interleukin 6 cytokine, iNOS, and COX-2 mRNA expression in the liver. Inflammatory cell infiltration was also significantly attenuated by the RVS extract or fustin supplementation. These results suggest that our standardized RVS extract has preventive effects on inflammatory reactions.
Authors	Ji Eun Moon, Jae-Ho Shin, Oran Kwon, Ji Yeon Kim
Journal	Journal of medicinal food (J Med Food) Vol. 18 Issue 11 Pg. 1223-30 (Nov 2015) ISSN: 1557-7600 [Electronic] United States
PMID	26501382 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Inflammatory Agents Antioxidants Flavonoids Inflammation Mediators Lipopolysaccharides Plant Extracts RNA, Messenger Nitric Oxide fustin Nitric Oxide Synthase Type II Nos2 protein, mouse Cyclooxygenase 2
Topics	Acute Disease Animals Anti-Inflammatory Agents (pharmacology, therapeutic use) Antioxidants (pharmacology) Cyclooxygenase 2 (metabolism) Flavonoids (pharmacology, therapeutic use) Inflammation (chemically induced, prevention & control) Inflammation Mediators (metabolism) Lipopolysaccharides Liver (drug effects, metabolism) Male Nitric Oxide (metabolism) Nitric Oxide Synthase Type II (metabolism) Phytotherapy Plant Extracts (pharmacology, therapeutic use) RNA, Messenger (metabolism) Rats, Wistar Reference Standards Rhus (chemistry)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!