Abstract | OBJECTIVE AND BACKGROUND DATA: METHODS: Twelve children undergoing HSCT were treated four times a week with a combined protocol of intraoral and extraoral LLLT, for a mean duration of 22 days. Clinical and functional mucositis scores were assessed using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE). These scores were compared with a matched retrospective control group of 12 children who did not receive LLLT during HSCT. RESULTS: Clinical mucositis scores were significantly lower in the LLLT group than in the control group (p = 0.004). Incidence of ulcerative oral mucositis was also significantly lower in the LLLT group (p = 0.027). Functional limitation associated with diet/swallowing was less severe in the LLLT group; however, this was not statistically significant. CONCLUSIONS: This study indicates that a combined protocol of intraoral and extraoral application of LLLT can reduce the severity of oral mucositis in pediatric patients undergoing HSCT. Randomized double-blind clinical trials with a larger number of subjects are needed to further test such combined protocols.
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Authors | Marcos Soto, Rajesh V Lalla, Roseane Vasconcelos Gouveia, Victor Gattardello Zecchin, Adriana Seber, Nilza Nelly Fontana Lopes |
Journal | Photomedicine and laser surgery
(Photomed Laser Surg)
Vol. 33
Issue 11
Pg. 540-6
(Nov 2015)
ISSN: 1557-8550 [Electronic] United States |
PMID | 26501372
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Child
- Child, Preschool
- Female
- Hematopoietic Stem Cell Transplantation
- Humans
- Low-Level Light Therapy
(methods)
- Male
- Mucositis
(prevention & control)
- Pilot Projects
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