Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model. | CureHunter

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Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model.

Abstract	Colon cancer liver metastasis is often the lethal aspect of this disease. Well-isolated metastases are candidates for surgical resection, but recurrence is common. Better adjuvant treatment is therefore needed to reduce or prevent recurrence. In the present study, HT-29 human colon cancer cells expressing red fluorescent protein (RFP) were used to establish liver metastases in nude mice. Mice with a single liver metastasis were randomized into bright-light surgery (BLS) or the combination of BLS and adjuvant treatment with tumor-targeting S. typhimurium A1-R. Residual tumor fluorescence after BLS was clearly visualized at high magnification by fluorescence imaging. Adjuvant treatment with S. typhimurium A1-R was highly effective to increase survival and disease-free survival after BLS of liver metastasis. The results suggest the future clinical potential of adjuvant S. typhimurium A1-R treatment after liver metastasis resection.
Authors	Takashi Murakami, Yukihiko Hiroshima, Ming Zhao, Yong Zhang, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M Hoffman
Journal	Oncotarget (Oncotarget) Vol. 6 Issue 39 Pg. 41856-62 (Dec 08 2015) ISSN: 1949-2553 [Electronic] United States
PMID	26497690 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References	Luminescent Proteins red fluorescent protein Green Fluorescent Proteins
Topics	Animals Biological Therapy (methods) Colonic Neoplasms (genetics, metabolism, pathology) Combined Modality Therapy Green Fluorescent Proteins (biosynthesis, genetics) HT29 Cells Hepatectomy Humans Liver Neoplasms (genetics, metabolism, microbiology, secondary, therapy) Luminescent Proteins (biosynthesis, genetics) Mice, Nude Neoplasm Recurrence, Local (prevention & control) Salmonella typhimurium (genetics, growth & development, metabolism, pathogenicity) Time Factors Transfection Xenograft Model Antitumor Assays

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